Research
Cyclodextrin-based structures for drug delivery
Cyclodextrins (CDs), cyclic oligomers linked by α-1,4 glycosidic bonds, are well known for their truncated cone structure, comprising a hydrophilic surface and a cavity bearing a hydrophobic microenvironment. Undoubtedly, the most acknowledged application is the enhancement of aqueous solubility of poorly soluble drugs through the formation of CD/drug ICs. However, the complexation can also protect drugs from heat, light, hydrolysis, and oxidation, thereby improving the stability of formulations. Native CDs and several CD-derivatives are FDA-approved for pharmaceutical use and their success is evident with more than 50 medications containing CDs currently marketed. The growth in the number of approved formulations over time suggests CDs are still a useful tool. The interest in CDs is still increasing and this trend is expected to continue in the coming years. Under this context, we are currently using CDs for enhancing the aqueous solubility of drugs for diverse therapeutic purposes.
